產品屬性：

Cas No.: 40456-50-6

別名: N/A

化學名: N/A

分子式: C22H24O7

分子量: 400.4

溶解度: Soluble in DMSO

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Yatein is a lignan that has been found in C. formosana and has diverse biological activities.1,2,3,4 It inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 1 μM).1 Yatein inhibits herpes simplex virus 1 (HSV-1) replication in a plaque reduction assay (IC50 = 30.6 μM).2 It induces apoptosis and production of reactive oxygen species (ROS) in, and is cytotoxic to, A549 and CL1-5 non-small cell lung cancer (NSCLC) cells (IC50s = 3.5 and 1.9 μM, respectively).3 Yatein inhibits aggregation of rabbit platelets induced by platelet-activating factor (PAF), collagen, or arachidonic acid in a concentration-dependent manner.4|1. Usia, T., Watabe, T., Kadota, S., et al. Potent CYP3A4 inhibitory constituents of Piper cubeba. J. Nat. Prod. 68(1), 64-68 (2005).|2. Kuo, Y.-C., Kuo, Y.-H., Lin, Y.-L., et al. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 70(3), 112-120 (2006).|3. Ho, S.-T., Lin, C.-C., Wu, T.-L., et al. Antitumor agent yatein from Calocedrus formosana Florin leaf induces apoptosis in non-small-cell lung cancer cells. J. Wood Sci. 65:59 , (2019).|4. Chen, J.-J., Chang, Y.-L., Teng, C.-M., et al. Anti-platelet aggregation alkaloids and lignans from Hernandia nymphaeifolia. Planta Med. 66(3), 251-256 (1999)."
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