產品屬性：

Cas No.: N/A

別名: N/A

化學名: N/A

分子式: C10H16NO9S2·K [XH2O]

分子量: 397.5

溶解度: : ,DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml

儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Sinigrin is a glucosinolate that has been found in Brassica and has diverse biological activities.1,2,3 It inhibits NOD-like receptor protein 3 (NLRP3) inflammasome activation in ATP-stimulated, LPS-primed RAW 264.7 cells in a concentration-dependent manner.1 Sinigrin (1-100 μg/ml) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 , as well as NF-κB activation, in RAW 264.7 cells. It induces cell cycle arrest at the G0/G1 phase in HepG2 hepatocellular carcinoma cells when used at concentrations of 0.1 and 0.5 mM.2 Sinigrin (10 and 20 mg/kg) reduces increases in renal glomerular basement membrane thickness, as well as increases in systolic and diastolic blood pressure, in a rat model of hypertension induced by angiotensin II.31.Lee, H.-W., Lee, C.G., Rhee, D.-K., et al.Sinigrin inhibits production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophagesInt. Immunopharmacol.45163-173(2017)

2.Jie, M., Cheung, W.M., Yu, V., et al.Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in ratsPLoS One9(10)e110145(2014)

3.Cong, C., Yuan, X., Hu, Y., et al.Sinigrin attenuates angiotensin II?induced kidney injury by inactivating nuclear factor?κB and extracellular signal?regulated kinase signaling in vivo and in vitroInt. J. Mol. Med.48(2)161(2021)
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