產(chǎn)品屬性：
產(chǎn)品名稱 | Trimethoprim-d3 |
規(guī)格 | 500 μg、1 mg |
貨號 | EY-01Y15002 |
Cas No.: 1189923-38-3
別名: N/A
化學名: N/A
分子式: C14H15D3N4O3
分子量: 293.3
溶解度: DMSO: Slightly Soluble,Methanol: Slightly Soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Trimethoprim-d3 is intended for use as an internal standard for the quantification of trimethoprim by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid.1,2 Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).2 Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.1.Lam, T., Hilgers, M.T., Cunningham, M.L., et al.Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolinesJ. Med. Chem.57(3)651-668(2014)
2.Schweitzer, B.I., Dicker, A.P., and Bertino, J.R.Dihydrofolate reductase as a therapeutic targetFASEB J.4(8)2441-2452(1990)
特別提醒公司產(chǎn)品僅供科研使用
