產品屬性：

Cas No.: 1189878-76-9

別名: N/A

化學名: N/A

分子式: C11H8D4N2O2S

分子量: 240.3

溶解度: DMSO: slightly soluble,Methanol: very slightly soluble

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Zileuton-d4 is intended for use as an internal standard for the quantification of zileuton by GC- or LC-MS. Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor.1 It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 μM. Zileuton inhibits leukotriene B4 production induced by the calcium ionophore A23187 in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC50 = 0.6 μM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge.2 Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.

1.Carter, G.W., Young, P.R., Albert, D.H., et al.5-Lipoxygenase inhibitory activity of zileutonJ. Pharmacol. Exp. Ther.256(3)929-937(1991)

2.Abraham, W.M., Ahmed, A., Cortes, A., et al.The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheepEur. J. Pharmacol.217(2-3)119-126(1992)
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