產(chǎn)品屬性：
產(chǎn)品名稱 | Tauro-β-muricholic Acid-d4 (sodium salt) |
規(guī)格 | 1 mg |
貨號(hào) | EY-01Y16269 |
Cas No.: N/A
別名: N/A
化學(xué)名: N/A
分子式: C26H40D4NO7S·Na
分子量: 541.7
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg/ml
儲(chǔ)存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Tauro-β-muricholic acid-d4 (TβMCA-d4) is intended for use as an internal standard for the quantification of TβMCA by GC- or LC-MS. TβMCA is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC50 = 40 μM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid .1 TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor.1,2 TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.31.Sayin, S.I., Wahlstr?m, A., Felin, J., et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonistCell Metab.17(2)225-235(2013)
2.Wahlstr?m, A., Kovatcheva-Datchary, P., St?hlman, M., et al.Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiotaJ. Lipid. Res.58(2)412-419(2017)
3.Qi, Y., Jiang, C., Cheng, J., et al.Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in miceBiochim. Biophys. Acta.1851(1)19-29(2015)
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